PERBANDINGAN EFEKTIVITAS NEFROPROTEKTOR EKSTRAK JINTAN HITAM (NIGELLA SATIVA) DENGAN EKSTRAK TEMULAWAK (CURCUMA XANTHORRHIZA) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS (RATTUS NOVERGICUS) YANG DIINDUKSI PARASETAMOL
Keywords:
Black Cumin Extract, Curcuma Extract, Nephroprotector, Paracetamol
Abstract
Over-use of paracetamol can cause nephrotoxicity. Black cumin and curcuma contain antioxidants that can ward off free
radicals produced by paracetamol metabolism. To compare the effectiveness of nephroprotector of black cumin extract and
curcuma extract on the histopathological picture of rats induced by paracetamol. True experimental, Post Test Only Control
Design. 24 rats were divided into 4 groups: negative control standard diet and aquades, positive group paracetamol dose
500 mg / kgBB, treatment 1 extract of black cumin extract 500 mg / kgBB, and treatment 2 curcuma extract 500 mg / kgBB.
After 30 minutes P1 and P2 were given a dose of paracetamol 500 mg / kg. Rats were dissected for kidney removal and
histopathological preparations were made. Degeneration, necrosis and bleeding of the proximal tubules were assessed by
scoring, comparison of scores between groups was assessed by the kruskal wallis test. There were nephroprotector effects
of black cumin and curcuma, with the same effectiveness on kidney damage induced by paracetamol. Black cumin can be
developed further as a nephroprotector.
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Ali J, Arshad A, Asif P, Rashid H, Imran M. Biomedicine & Pharmacotherapy Protective e ff ects of Cinnamomum zeylanicum
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Yayla M, Halici Z, Unal B, Bayir Y, Akpinar E, Gocer F. Protective effect of Et-1 receptor antagonist bosentan on paracetamol
induced acute liver toxicity in rats. Eur J Pharmacol. 2014;726(1):87-95.
Cekmen M, Ilbey YO, Ozbek E, Simsek A, Somay A, Ersoz C. Curcumin prevents oxidative renal damage induced by
acetaminophen in rats. Food Chem Toxicol. 2009;47(7):1480-1484.
paracetamol-induced renal inflammation. 2018;11:1-11.Moshaie-nezhad P, Hosseini SM, Yahyapour M, Iman M. Protective
effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice. 2019;8(1):64-68.
Canayakin D, Bayir Y, Baygutalp NK, et al. Paracetamol-induced nephrotoxicity and oxidative stress in rats : the protective
role of Nigella sativa. 2016;0209.
Kidney RATS, High G, Of D. Pengaruh Pemberian Propolis Terhadap Gambaran Histopatologi Ginjal Tikus Putih yang
Diberikan Parasetamol Dosis Tinggi. 2017;9(1):9-15.
Chinnappan SM, George A, Thaggikuppe P, et al. Nephroprotective Effect of Herbal Extract Eurycoma longifolia on
Paracetamol-Induced Nephrotoxicity in Rats. 2019;2019.
Ali MY, Morshed MR, Hossen MS, et al. Antioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus
lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in Rats. Am J Pharmacol Toxicol. 2018;13(1):16-29.
Safarsyah AI. Hadits nabi saw tentang obat dalam tinjauan ilmu kedokteran modern. 2018;12(2).
Hamdy R, Salama M, Abd-el-hameed NA. Nephroprotective Effect of Nigella sativa and Matricaria chamomilla in Cisplatin
Induced Renal Injury. 2011;2011(July):185-195.
Sholihah R, Haris MS, Abror YK. Analysis of APO – B Serum Level in Balb/C Mice Hypercholesterolemic Against Temulawak
Extract (Curcuma xanthoriza Roxb). 2019.
Shakti SW, Ismail A, Bambangwitjahyo RB. Pengaruh Pemberian Ekstrak Temulawak (Curcuma xanthorrhiza) Dosis
Bertingkat Terhadap Gambaran Mikrokropis Ginjal Mencit Balb / c Jantan. 2019;8(1):509-522.
Klarissa C. Uji Efek Pemberian Ekstrak Temulawak (Curcuma xanthorrhiza roxb.) terhadap Gambaran Histopatologi Ginjal
Tikus Putih Jantan Galur Wistar yang Diinduksi Parasetamol. 2016.
Federer W. Experimental Design, Theory and Application. New York, Mac Millan; 1963.
Ozatik FY, Teksen Y, Kadioglu E, Ozatik O, Bayat Z. Effects of hydrogen sulfide on acetaminophen-induced acute renal
toxicity in rats. Int Urol Nephrol. 2019;0(0):0.
Srinivasan V, Panneerselvam R, Gunasekaran S, Palani S. Ethanolic extract of Melia Azadirachta against acetaminophen
induced nephrotoxicity. Int J PharmTech Res. 2014;6(1):70-79.
Wudil A, Sarki S. The effect of aqueous stem bark extract of Erythrina mildbraedii on acetaminophen induced nephrotoxicity
in rats. Bayero J Pure Appl Sci. 2015;8(1):10.
Miyahara T. Drug-induced renal disorders. Nippon rinsho Japanese J Clin Med. 1978;Suppl(3):2320-2321.
Kandemir FM, Kucukler S, Eldutar E, Caglayan C. Chrysin Protects Rat Kidney from Paracetamol-Induced Oxidative Stress ,
Inflammation , Apoptosis , and Autophagy : A Multi-Biomarker Approach.
Azzami NA, Nugroho TE, Serum U. Parasetamol dan Morfin Terhadap Kadar Ureum Serum. 2019;8(1):323-332.
Mescher AL. Histologi Dasar Junqueira Teks & Atlas. 14th ed. (Susanti F, Wijaya HS, Agustina L, Agustin S, Sadikin RE,
eds.). Jakarta: EGC; 2014.
Vinay Kumar, Ramzi S. Cotran SLR. Buku Ajar Patologi Robbins Volume 1. VII. Jakarta: EGC; 2007.
Khrestyawan. Pengaruh Pemberian Ekstrak Biji Kakao (Theobroma Cacao) Terhadap Kerusakan Sel Ginjal Mencit (mus
Mucukus) Yang Diinduksi Parasetamol. 2010;0(November):210.
Kushwah, D S. Salman, M T. Singh, P. Verma, V K. Ahmad A. Protective Effects of Ethanolic Extract of Nigella sativa Seed
in Paracetamol Induced Acute Hepatotoxicity In vivo. Pakistan J Biol Sci. 2014;17(4):517-522.
Hosseinian S, Hadjzadeh M, Roshan NM, Khazaei M. of Kidney Diseases and Transplantation Original Article
Renoprotective Effect of Nigella sativa against Cisplatin-induced Nephrotoxicity and Oxidative Stress in Rat. 2018;29(1):19-
29.
Seran IC. Pengaruh Ekstrak Etanol Biji Jinten Hitam (Nigella sativa l.) terhadap Antihiperglikemik dan Histologi Ginjal pada
Tikus Diabetes Nefropati yang Diinduksi Aloksan. 2019:1-80.
Ali J, Arshad A, Asif P, Rashid H, Imran M. Biomedicine & Pharmacotherapy Protective e ff ects of Cinnamomum zeylanicum
L . (Darchini) in acetaminophen-induced oxidative stress , hepatotoxicity and nephrotoxicity in mouse model. 2019;109:2285-
2292.
Yayla M, Halici Z, Unal B, Bayir Y, Akpinar E, Gocer F. Protective effect of Et-1 receptor antagonist bosentan on paracetamol
induced acute liver toxicity in rats. Eur J Pharmacol. 2014;726(1):87-95.
Cekmen M, Ilbey YO, Ozbek E, Simsek A, Somay A, Ersoz C. Curcumin prevents oxidative renal damage induced by
acetaminophen in rats. Food Chem Toxicol. 2009;47(7):1480-1484.
Published
2021-06-22
How to Cite
HANDAYANI, K., SURYANI, D., & LUBIS, H. (2021). PERBANDINGAN EFEKTIVITAS NEFROPROTEKTOR EKSTRAK JINTAN HITAM (NIGELLA SATIVA) DENGAN EKSTRAK TEMULAWAK (CURCUMA XANTHORRHIZA) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS (RATTUS NOVERGICUS) YANG DIINDUKSI PARASETAMOL. JURNAL ILMIAH MAKSITEK, 6(2), 120-127. Retrieved from https://makarioz.sciencemakarioz.org/index.php/JIM/article/view/257
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