PENGARUH PEMBERIAN DAGING BUAH DURIAN ( Durio Zibethinus ) TERHADAP FUNGSI GINJAL (UREUM DAN KREATININ) TIKUS PUTIH ( Rattus Norvegicus L.) JANTAN GALUR WISTAR

RAJA IQBAL ALAMSYAH; ROBITAH ASFUR

RAJA IQBAL ALAMSYAH FAKULTAS KEDOKTERAN, UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA,INDONESIA
ROBITAH ASFUR DEPARTEMEN FISIOLOGI, FAKULTAS KEDOKTERAN, UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA,INDONESIA

Keywords: Kidney, Creatinine, Durian, Urea

Abstract

Examination of serum urea and creatinine levels is important to determine the physiological condition of the kidneys. Patients with kidney disease, especially those with kidney failure, are strongly advised to maintain a pattern of consuming durian, high levels of potassium in durian can be at risk of experiencing hyperkalemia. Consuming durian which is high in potassium will be one of the factors for the occurrence of AKI. The most famous durian fruit species in Indonesia is Durio zibethinus. Durian comes from the forests of Sumatra, Malaysia and also Kalimantan which are wild plants. To determine the effect of giving durian (Durio Zibethinus) pulp on changes in kidney function (creatinine and urea) in male white rats (Rattus Norvegicus L) Wistar strain. True Experiment with a "posttest with control group design" as many as 4 groups were given treatment for 28 days. Urea and creatinine levels were tested. Data analysis was carried out by One Way Anova post hoc Bonferroni and Kruskall Wallis. There was an effect of giving durian with graded doses in groups P1, P2 and P3 which was significant compared to the negative group. For comparisons between groups P1, P2 and P3 the results were not significant (p> 0.05). Conclusion: giving durian with graded doses has an effect on increasing Ureum and Creatinine levels in rat kidney function.

References

Arjani I. Gambaran Kadar Ureum Dan Kreatinin Serum Pada Pasien Gagal Ginjal Kronis (Ggk) Yang Menjalani Terapi Gounden V, Harshil B, Ishwarlal J. Renal function test. StatPearls Publishing LLC. 2021;20
Hemodialisis Di Rsud Sanjiwani Gianyar. Meditory J Med Lab. 2017;4(2):145–153. doi:10.33992/m.v4i2.64
Muhammad E, Ashari S. Analisis Klaster Durian ( Durio zibethinus Murr .) Unggul Lokal di Kecamatan Kasembon. J Produksi Tanam. 2019;7(7):1347–1353.
Redaksi Trubus. Berkebun Durian Ala Petani Thailand. Jakarta :
Penebar Swadaya, 2017 Pertanian TTGB. D u r i a n (. :1–18.Darah KD. Pengaruh pemberian daging buah durian (.; 2013.
Leo CLB, Leong WS, Tieh CS, Liew CK. Durian induced hyperkalaemia. Med J Malaysia. 2011;66(1):66–67.
Ronco C, Bellomo R, Kellum J, Ricci Z. Critical Care Nephrology (3rd edition). Philadelphia: Elsevier,2019.
Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders HJ. Acute kidney injury. Nat Rev Dis Prim.2021;7(1).doi:10.1038/s4 1572-021-00284-z.
Riskesdas. Laporan Nasional RISKESDAS 2018;10:126.doi:10.12688/f1000research.4 6544.1.
Riskesdas. Laporan Provinsi Sumatera Utara Riskesdas 2018.; 2018.
Srinivasan V, Panneerselvam R, Gunasekaran S, Palani S. Ethanolic extract of Melia Azadirachta
against acetaminophen-induced nephrotoxicity.Int J PharmTech Res. 2014;6(1):70-79.
Wudil A, Sarki S. The Effect Of Aqueous Stem Bark Extract Of Erythrina Mildbraedii On Acetaminophen Induced
Nephrotoxicity In Rats. Bayero J Pure Appl Sci. 2015;8(1):10. Doi:10.4314/Bajopas.V8i1.3
Payus AO, Ahmedy F, Syed Abdul Rahim SS, Sumpat D. An uncommon side effect from the ‘king of fruit’: A case report on life-threatening hyperkalaemia after eating durian fruit. SAGE Open Med Case Reports.2021;9(October). doi:10.1177/2050313X211063 195